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Manufacturer: Arbor Assays

TNF-alpha is the prototypic pro-inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signaling events within cells.1 TNF-alpha is also important for resistance to infection and cancers.2 It is central to host defense and inflammatory responses but under certain circumstances also triggers necrosis or apoptosis. Its pleiotropic effects often lead to opposing outcomes during the development of immune-mediated diseases such as cancer, Alzheimer’s, inflammatory bowel disease, Crohn’s Disease, ulcerative colitis, rheumatoid arthritis, psoriatic arthritis, psoriasis, and noninfectious uveitis.3,4,5 As a result, a number of TNF-alpha therapies and biologic agents have been FDA approved.6,7.

Manufacturer: Arbor Assays

Thyroid hormones regulate a number of developmental, metabolic, and neural activities throughout the body. The thyroid gland synthesizes 2 hormones: Thyroxine, which contains 4 atoms of iodine (T4), and triiodothyronine (T3), which has 3 atoms of iodine. T3 production in the thyroid gland constitutes approximately 20% of the total T3; the rest is generated by the conversion (deiodination) of T4 to T3 in peripheral tissues. Circulating levels of T4 are much greater than T3 levels, but T3 is biologically the most metabolically active hormone (3-4 times more potent than T4) although its effect is briefer due to its shorter half-life. Thyroid hormones circulate primarily bound to carrier proteins (eg, thyroid-binding globulin [TBG], prealbumin and albumin); whereas only a small fraction circulates unbound (free). The free form of T3 is the biologically active fraction. While both T3 and T4 are bound to TBG, T3 is bound less firmly than T4. Total T3 consists of both the bound and unbound fractions.

Manufacturer: BT Lab

Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology.

Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Human Interleukin 1 beta (also known as IL1B) in serum, plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.

Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Human Tumor Necrosis Factor alpha (also known as TNFA) in serum plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.

Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Human Neutrophil Gelatinase-Associated Lipocalin (also known as LCN2) in serum, plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.

Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Human Interferon Gamma (also known as IFNG) in serum, plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.

Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Rat Interleukin 6 (also known as IL6) in serum, plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.

Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Human Interleukin 18 (also known as IL18) in serum, plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.