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Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Human High Mobility Group Protein B1 (also known as HMGB1) in serum, plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.

Manufacturer: BT Lab

Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed: 11323673, PubMed: 18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed: 29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed: 20855887, PubMed: 11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).

Manufacturer: BT Lab

Participates in at least several B-cell activation processes as well as of other cell types (PubMed: 3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).

Manufacturer: BT Lab

Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed: 28541286, PubMed: 28073925, PubMed: 18378771, PubMed: 28453791, PubMed: 12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed: 28453791, PubMed: 28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed: 28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed: 12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed: 18378771). [Granulin-4]: Promotes proliferation of the epithelial cell line A431 in culture. [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.

Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Human Transforming Growth Factor beta1 (also known as TGFB1) in serum, plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.

Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Mouse Interleukin 6 (also known as IL6) in serum, plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.

Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Bovine Insulin-like Growth Factors 1 (also known as IGF1) in serum, plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.

Manufacturer: BT Lab

This Sandwich kit is for the accurate quantitative detection of Rat Catalase (also known as CAT) in serum, plasma, cell culture supernatants, Ascites, tissue homogenates or other biological fluids.

Manufacturer: BT Lab

This Competitive ELISA kit is for the quantification of Mouse Immunoglobulin G (also known as IgG) in serum, plasma, cell culture supernatants, urine, tissue homogenates or other biological fluids.